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Job Description

Job Description

Description :

VP Oligonucleotide Therapeutics

Palo Alto, CA

About GondolaBio

GondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases. GondolaBio is an independent sister company to BridgeBio, originally carved out in 2024 after securing $300M in private financing from external investors. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.

Who You Are

You are an accomplished leader in oligonucleotide drug discovery and development, with a

strong track record of advancing oligonucleotides (conjugated and unconjugated) from concept

through development candidate (DC) nomination and into IND. You bring deep expertise in

assay development, oligo design, and translational research, and you thrive in owning programs

end-to-end. While hands-on when needed, you excel at setting scientific vision, leading cross-

functional execution, and ensuring rigorous decision-making in a lean, high-impact environment.

Key Responsibilities

• Program ownership : Serve as program owner for oligonucleotide discovery and

development programs, driving them from target validation through DC nomination and IND

submission.

oligonucleotides and siRNAs, with a particular emphasis on conjugated oligos (e.g., GalNAc,

peptide, antibody, or other ligand-based conjugates).

oligo potency, specificity, uptake, trafficking, and mechanism of action. Ensure assay

platforms are robust, scalable, and reproducible.

optimize conjugated oligos; directly contribute to design hypotheses and screen conjugates

in relevant cellular and in vivo models.

making to select and nominate oligo development candidates for IND-enabling studies.

preclinical data, biomarkers, and mechanistic insights into regulatory filings.

with human biology. Develop and integrate biomarker strategies to guide dose selection,

patient stratification, and early clinical readouts.

alignment across biology, chemistry, DMPK, CMC, toxicology, and clinical groups to deliver

on program objectives.

accelerate program timelines while ensuring scientific rigor and data quality.

including IND packages, Investigator’s Brochures, and briefing books.

Preferred Education & Experience

years in a leadership role.

programs into IND.

translational / biomarker strategy.

Nice-to-Haves

clinical development.

No matter your role at GondolaBio, successful team members are

mindset

and speed

What We Offer

conditions we are seeking to impact throughout the year and learn how we can improve our

efforts

transparent, every minute counts, and let the science speak

helping patients. Our affiliate structure is designed to eliminate bureaucracy and put

decision-making power in the hands of those closest to the science

other to always perform at the top of our game

shape of your life

Bonus, Equity, health, welfare & retirement programs)

therapeutic areas over time

The base pay range for this position is $290,000 to $340,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.

Requirements :