Senior Scientist II, DMPK

SUMMARY : The Senior Scientist II, DMPK works with a fast-paced team in drug discovery research to provide scientific direction and strategy to find a potential safe and effective human dose through the design, analysis, and interpretation of in vitro and in vivo pharmacology and DMPK experiments along with modeling and simulation. The successful candidate will utilize their strong knowledge in ADME and PK / PD to equally partner with team members within medicinal chemistry, biology, toxicology, and pharmacology, to drive programs forward and to actively engage with key stakeholders and leaders to achieve critical milestones for Exelixis' pipeline. Primary responsibilities will be to generate hypotheses to improve the DMPK profile of drug candidates, independently plan and execute experiments through data-driven approaches, and integrate ADME with the pharmacology of target(s) through modeling and simulations to support human dose projections.

ESSENTIAL DUTIES AND RESPONSIBILITIES :

• Collaborate with discovery colleagues to evaluate compound properties for new compound selections; represent the department on project teams as the subject matter expert on DMPK.
• Work with key stakeholders to design and to interpret PK, toxicology and pharmacology studies.
• Lead Modeling and Simulation efforts to establish relationship between drug concentration to PD / efficacy / toxicity and to identify potential drug interaction liabilities.
• Closely partner with Discovery and Development leadership to evolve PK / PD and PBPK strategies, and lead roll-out, education and execution to ensure deep integration into Discovery projects.
• Closely partner with Clinical Pharmacology to ensure a seamless transition to Development and to enhance interaction with regulatory agencies.
• Maintain external scientific visibility through publication.
• Foster a science-driven, goal-oriented culture that values innovation, teamwork, agility, transparency, accountability, and empowerment
• Conduct scientific presentations to senior m an a g e m ent, project teams, and internal / external collaborators.
• C o m ply w ith co m pany health and safety policies and g eneral laboratory practices.

SUPERVISORY RESPONSIBILITIES :

EDUCATION / EXPERIENCE / SKILLS :

Education :

Experience :

Knowledge / Skills / Abilities :

WORKING CONDITIONS

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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!

Our compensation reflects the cost of labor across severalU.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this positionis $128,500 - $181,500 annually. The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors.

In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.

DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.