Vice President, International General Manager

Vice President, International General Manager

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.

As Immunome prepares to bring varegacestat to global markets, we are seeking a seasoned, strategic, and execution-focused Vice President, International General Manager to build and lead the commercialization of the product outside the United States.

This person will be responsible for designing and executing the global (ex-U.S.) launch strategy, beginning with Europe (EMA) and expanding into priority markets worldwide. The role encompasses global launch planning, supply chain and distribution strategy, commercial readiness, market access planning, country-level business modeling, and partnership evaluations.

The ideal candidate brings extensive global oncology experience, proven success shaping international brand strategies, and a strong ability to lead across geographies and functions. A profile reflected in the experience of top candidates with backgrounds in global commercial leadership, global launch strategy, pricing and access, cross-cultural team leadership, and P&L responsibility.

This is a rare opportunity to architect Immunome's international business from the ground up.

Responsibilities

• Develop and lead the international launch strategy for varegacestat, with initial focus on EMA markets and sequencing expansion into additional key regions (e.g., UK, Australia, LATAM, APAC).
• Define launch sequencing and global commercialization roadmaps, including regulatory milestones, market development, and country readiness plans.
• Establish core elements of global positioning, education strategy, and global value narrative based on patient, provider, and payer insights.
• Represent international commercial needs across cross-functional global teams, consistent with experience collaborating with Clinical Development, Regulatory, Market Access, and Medical Affairs.
• Partner with Regulatory Affairs to oversee EMA submission and approval strategy, including coordination of requirements for key EU markets.
• Develop global pricing, access, and reimbursement strategies aligned to diverse healthcare and HTA systems, consistent with global access and pricing experience.
• Guide development of clinical and real-world evidence (RWE) packages to support HTA assessments and reimbursement negotiations in global markets.
• Build and oversee a compliant, efficient global supply chain and distribution strategy, including import / export planning, distribution partners, serialization, and local regulatory and quality requirements.
• Evaluate and manage third-party logistics (3PL), distributors, wholesalers, and in-country representative models.
• Ensure international markets have the infrastructure needed for commercial launch, including promotional resource development aligned with global brand leadership experience.
• Conduct build-versus-partner analyses for each market, assessing potential distributors, commercial partners, or co-promotion opportunities.
• Negotiate commercial, access, and distribution partnerships to accelerate global reach.
• Serve as the senior international representative with global KOLs, regulatory bodies, HTA groups, and advocacy organizationsleveraging skills in global KOL relations and stakeholder engagement.
• Oversee international P&L for varegacestat and future products, consistent with prior P&L responsibility.
• Build the international Immunome organization, which may include commercial, medical, access, and operational roles across geographies.
• Develop annual operating plans, forecasting processes, and governance frameworks for ex-U.S. business operations.
• Operate as a key member of the Commercial Leadership Team, ensuring alignment between U.S. and global commercial strategies.
• Lead cross-functional engagement with Clinical, Regulatory, Medical, Global Market Access, Finance, Legal, and Supply Chain.
• Bring global insights and competitive intelligence to pipeline planning and lifecycle management, leveraging demonstrated expertise in competitive monitoring and lifecycle strategy.

Qualifications

Knowledge and Skills

Washington State Pay Range

$334,098 - $386,813 USD

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.