Senior Data Scientist, Science

The Chan Zuckerberg Initiative was founded by Priscilla Chan and Mark Zuckerberg in 2015 to help solve some of society’s toughest challenges — from eradicating disease and improving education to addressing the needs of our local communities. Our mission is to build a more inclusive, just, and healthy future for everyone.

The Team

CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease.

Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems — paving the way for new discoveries that will change medicine in the decades that follow :

• Building an AI-based virtual cell model to predict and understand cellular behavior
• Developing state-of-the-art imaging systems to observe living cells in action
• Instrumenting tissues to better understand inflammation, a key driver of many diseases
• Engineering and harnessing the immune system for early detection, prevention, and treatment of disease

CZI’s work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science.

As a Senior Data Scientist, you'll lead the creation of groundbreaking datasets that power our AI / ML efforts within and across our scientific grand challenges. Working at the intersection of data science, biology, and AI, your work will focus on creating large, AI-ready datasets, spanning single-cell sequencing, immune receptor profiling, and mass spectrometry peptidomics data. You will define data needs, format standards, analysis approaches and quality metrics and build pipelines to ingest, transform, and validate data products that form the foundation of our experiments.

Our Data Ecosystem :

These efforts will form a part of, and interoperate with CZI's larger data ecosystem. We are generating unprecedented scientific datasets that drive biological innovation :

When analysis of a dataset is complete, you will help publish it through public resources like CELLxGENE Discover, the CryoET Portal, and the Virtual Cell Platform, used by tens of thousands of scientists monthly to advance understanding of genetic variants, disease risk, drug toxicities, and therapeutic discovery.

Your Impact

You'll collaborate with cross-functional teams to lead dataset definition, ingestion, transformation, and delivery for AI modeling and experimental analysis. Success means delivering high-quality, usable datasets that directly address modeling challenges and accelerate scientific progress. Join us in building the data foundation that will transform our understanding of human biology and move us along the path to curing, preventing, and managing all disease.

What You'll Do

What You'll Bring

Compensation

The Redwood City, CA base pay range for this role is $190,000 - $261,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.

Work Mode

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.

Benefits for the Whole You

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

Explore our  work modes ,  benefits , and  interview process  at  www.chanzuckerberg.com / careers .

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