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Senior Research Associate (Assay Development) Contract
Senior Research Associate (Assay Development) ContractDELFI Diagnostics • Palo Alto, California, USA
Senior Research Associate (Assay Development) Contract

Senior Research Associate (Assay Development) Contract

DELFI Diagnostics • Palo Alto, California, USA
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About Us

DELFI Diagnostics Inc. (DELFI Diagnostics) is developing next-generation blood-based tests that are reliable accessible and deliver a new way to help detect cancer. Employing advanced machine-learning methods to whole-genome sequencing data the DELFI (DNA EvaLuation of Fragments for early Interception) platform is built to address the highest-burden health challenges. DELFI Diagnostics prioritizes solutions that have the potential to save lives on a global scale including for historically underserved populations. DELFI Diagnostics platform relies on fragmentomics the discovery that cancer cells are more chaotic than normal cells and when they die leave behind tell-tale patterns and characteristics of cell-free DNA (cfDNA) fragments. FirstLook Lung for individuals eligible for lung cancer screening is DELFI Diagnostics first laboratory-developed screening test and can be part of routine blood work. FirstLook Lung uses millions of data points to reliably identify individuals who may have cancer detected through low-dose CT including early-stage disease with a negative predictive value of 99.8 percent. This test has not been cleared or approved by the FDA.

In our passionate pursuit to radically improve health outcomes we serve humanity when we :

Lead with Science Anchor in Pragmatism : We pioneer life-changing science by ensuring quality transparency and rigor at all times. We explore thoughtfully experiment smartly and deliver impact with conviction.

Build With & For All : We embrace diverse backgrounds to innovate and achieve together. We are not just building a product - we aim to disrupt the path of cancer for all - no matter geography or socioeconomic class

Put We over I : We are a home for high-performing people. Through teamwork we build collective intelligence. Each of us wins when those we serve and those who serve with us win. We show up with empathy humility and integrity at every step of the journey.

About the Role

Join our innovative team dedicated to reducing cancer deaths through cutting-edge liquid biopsy diagnostics. As Sr. Research Associate you will play a critical role in developing and validating next-generation sequencing assays from concept through commercial launch working within a collaborative environment of scientists engineers and bioinformaticians. You will contribute to product development verification and validation activities for NGS-based laboratory tests for early cancer detection. The ideal candidates would have experience working under Good Laboratory Practice (GLP) in a CAP / CLIA / FDA-regulated environment.

What youll do

  • Contribute to the success of a cohesive innovative motivated team that is dedicated to reducing cancer deaths through the following activities :
  • Design execute and troubleshoot moderate to complex laboratory experiments utilizing molecular biology techniques for Next-Generation Sequencing (NGS).
  • Perform end-to-end experimental workflows including nucleic acid extraction library preparation and sequencing while preparing samples and executing experiments with meticulous attention to detail and adherence to high-quality standards.
  • Develop robust assay workflows by performing guard banding studies and verifying product requirements with analytical characterization studies.
  • Communicate findings effectively with multidisciplinary teams including biologists bioinformaticians statisticians automation engineers and quality control scientists and present at scientific meetings.
  • Contribute to advancing assays through design control processes to meet product requirements and regulatory standards by maintaining comprehensive documentation.

What youll have accomplished 6 months from now

  • Identified critical quality assay parameters and developed assay specifications to establish a robust assay workflow for DELFIs lung cancer screening test.
  • Become an expert operator of DELFIs NGS laboratory process
  • Proven track record of organization and cross-functional communication for study preparation and execution
  • What youll bring to DELFI

  • Required qualifications :
  • BS with 3-4 years of experience or MS with 2-3 years relevant field (e.g. biomedical engineering molecular biology genetics or genomics) in assay development for the life science industry
  • Proficient in high-throughput manual laboratory techniques including precision pipetting for large-scale sample processing
  • Proven track record in laboratory method optimization with specialized expertise in addressing technical challenges specific to nucleic acid extraction and library preparation for NGS.
  • Strong analytical skills with demonstrated ability to independently design experiments and interpret results using sound scientific reasoning
  • Excellent technical writing capabilities for developing experimental protocols standard operating procedures and comprehensive development reports
  • Superior organizational and project management abilities including meticulous documentation practices strategic planning and effective time management with keen attention to detail
  • Preferred qualifications :

  • Hands-on experience with automated liquid handling systems for assay development and execution
  • Advanced data analysis skills using Excel and statistical software packages; programming experience in Python R or similar languages is highly valued
  • Direct experience in a regulated environment (CLIA CAP NYS FDA GXP etc.)
  • $110000 - $135000 a year

    An equal opportunity employerWe are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race religion color national origin gender sexual orientation age marital status veteran status or disability status.

    We may use artificial intelligence (AI) tools to support parts of the hiring process such as reviewing applications analyzing resumes or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed please contact us.

    Required Experience :

    Senior IC

    Key Skills

    Laboratory Experience,Immunoassays,Mammalian Cell Culture,PCR,Biochemistry,Assays,Cell Biology,Research Experience,Cell Culture,Molecular Biology,Flow Cytometry,Western Blot

    Employment Type : Contract

    Experience : years

    Vacancy : 1

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