Postdoctoral Fellow
Berkeley Lab's (LBNL) Molecular Biophysics and Integrated Bioimaging Division (MBIB) has an opening for a Postdoctoral Fellow to develop computational methods and software for protein structure determination.
In this exciting role, you will develop new mathematical approaches and computational algorithms to investigate protein conformational states from cryo-electron microscopy (Cryo-EM) experiments, including single-particle imaging and cellular tomography. This work will involve research and development of new hybrid methods that combine deep generative modeling, traditional optimization-based methods, numerical linear algebra, and Fourier analysis.
The goals include writing a pipeline for automated atomic modeling of heterogeneous structures from cryo-EM data using Phenix model building tools and developing methods for dealing with incomplete data and structure completion. You will work with a data analysis team for image analysis and the Phenix team for model building aspects. This position will require implementation and testing of software on simulated and experimental data, organization of results for presentations to team members and to the scientific community and preparing results for publication in scientific journals. This position has an anticipated start date of August 1, 2025.
What You Will Do :
Develop and implement computational algorithms for structure determination using cryo-electron microscopy including :
Apply new algorithms to enable high-resolution 3D reconstructions of biomolecules from cellular tomographic data.
Publish scientific papers in high-impact journals and present findings at seminars and conferences.
Maintain documentation of theory, derivations, software, and results.
Contribute to discussions on the determination of future directions.
Prepare results, figures, and write-ups for research / grant proposals.
What is Required :
Desired Qualifications :
Notes :
Equal Employment Opportunity Employer : The foundation of Berkeley Lab is our Stewardship Values : Team Science, Service, Trust, Innovation, and Respect; and we strive to build community with these shared values and commitments. Berkeley Lab is an Equal Opportunity Employer. We heartily welcome applications from all who could contribute to the Lab's mission of leading scientific discovery, excellence, and professionalism. In support of our rich global community, all qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories under State and Federal law. Berkeley Lab is a University of California employer. It is the policy of the University of California to undertake affirmative action and anti-discrimination efforts, consistent with its obligations as a Federal and State contractor. Misconduct Disclosure Requirement : As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct, are currently being investigated for misconduct, left a position during an investigation for alleged misconduct, or have filed an appeal with a previous employer.
Postdoctoral Fellow • San Francisco, CA, US