Technical Project Manager

Technical Project Manager

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

Summary

RayzeBio is seeking a dynamic and experienced Technical Project Manager with a strong engineering background and substantial capital project management expertise to lead the construction and operational ramp-up of a new radiopharmaceutical manufacturing facility in Indiana. The Technical Project Manager will transfer to the new facility site upon commencement of construction. In addition to managing the facility build, this role will have a significant focus on overseeing the integration and commissioning of advanced manufacturing technologies and systems critical to radiopharmaceutical production. The candidate will work closely with the Head of Program Management, the Head of Capital Project Engineering, and the Bristol Myers Squibb team to ensure alignment across all technical, engineering, and operational aspects of the project. The ideal candidate will possess in-depth knowledge of clean room design, operation, and regulatory requirements, as well as hands-on experience with the installation and commissioning of hot cells for radiopharmaceutical manufacturing. The Technical Project Manager will ensure all phases of facility construction and transition to production are delivered on schedule, within scope, and in compliance with regulatory and quality standards. This position reports directly to the Head of Program Management.

Job Responsibilities

Lead end-to-end project management for the construction and commissioning of a new radiopharmaceutical manufacturing site and process technologies, from design through validation and production launch.

Track facility construction activities, coordinating with contractors, architects, engineers, and internal stakeholders.

Serve as the primary liaison between construction teams, manufacturing operations, engineering, and regulatory affairs to ensure alignment and timely decision-making.

Develop and manage detailed project timelines, budgets, and resource allocations; proactively identify and mitigate risks.

Ensure all facility design and construction activities adhere to Good Manufacturing Practices (GMP) and regulatory requirements for radiopharmaceutical production.

Manage internal and external project teams, providing clear direction, accountability, and communication.

Prepare and deliver regular updates and presentations to the Head of Program Management, executive leadership, and external partners.

Plan and facilitate the transition from construction to operational readiness, including facility qualification, equipment validation, and staff training.

Implement project management tools and best practices for tracking progress, reporting, and documentation.

Foster a culture of safety and compliance, ensuring all personnel follow environmental, health, and safety (EHS) protocols, including the use of PPE in radioactive material environments.

Education and Experience

Bachelor's degree in engineering (civil, mechanical, chemical, or related field) required.

Minimum of 5 years of project management experience in pharmaceutical or radiopharmaceutical manufacturing, with direct responsibility for facility construction or major capital projects ranging from $10 million to $150 million.

In-depth knowledge of GMP, FDA requirements, and regulatory considerations for radiopharmaceuticals.

Prior experience managing large-scale construction projects in a regulated manufacturing environment.

Skills and Qualifications

Proficient with project management tools and software (e.g., MS Office Microsoft Project, ERP systems such as SAP).

Strong knowledge of radiopharmaceutical production processes and facility operational requirements.

Excellent organizational, multitasking, and analytical skills.

Ability to lead cross-functional teams and effectively communicate at all organizational levels.

Demonstrated ability to handle confidential information and manage complex stakeholder relationships.

Strong long-term planning, resource management, and risk mitigation abilities.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and / or move up to 50 pounds. Specific vision abilities required by this job include close vision and distance vision. Must be willing to wear personal protective equipment (PPE) for long periods. This is a position that may require working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

Work Environment

The noise level in the work environment is usually moderate.