Senior Computational Chemist, Drug Discovery

About SandboxAQ

SandboxAQ is a high-growth company delivering AI solutions that address some of the worlds greatest challenges. The companys Large Quantitative Models (LQMs) power advances in life sciences financial services navigation cybersecurity and other sectors.

We are a global team that is tech-focused and includes experts in AI chemistry cybersecurity physics mathematics medicine engineering and other specialties. The company emerged from Alphabet Inc. as an independent growth capital-backed company in 2022 funded by leading investors and supported by a braintrust of industry leaders.

At SandboxAQ weve cultivated an environment that encourages creativity collaboration and impact. By investing deeply in our people were building a thriving global workforce poised to tackle the worlds epic challenges. Join us to advance your career in pursuit of an inspiring mission in a community of like-minded people who value entrepreneurialism ownership and transformative impact.

About the Role :

SandboxAQs AI Simulation team develops novel drugs and materials by integrating AI and physics-based computational solutions. Our AQBioSim group seeks a computational chemist who will not only apply cutting-edge methodologies but also critically assess and refine computational approaches. This individual will challenge assumptions ask why when interpreting results and ensure the reliability and accuracy of findings rather than blindly trusting outputs.

This role will drive innovation by combining quantum AI and physics-based methodssuch as molecular dynamics and active learning free energy perturbationto advance drug discovery. Working within a highly skilled and multidisciplinary team including drug hunters with a strong track record in drug discovery computational chemists physicists AI experts and software engineers you will play a key role in shaping the future of computational drug design.

What Youll Do :

• Apply computational solutions to address unmet drug discovery challenges questioning assumptions and rigorously validating results.
• Work closely with the development team to enhance SandboxAQs unique technology and Large Quantitative Models (LQMs) for large-scale impact.
• Apply SandboxAQs computational platform to provide high-value drug discovery solutions while critically evaluating its methodologies and results.
• Translate insights from molecular dynamics free energy perturbation molecular docking quantum and ML methods into actionable testable drug discovery hypotheses.
• Collaborate closely with ML experts and cross-functional teams to prototype and scale innovative drug design solutions.
• Develop and deploy computational methods and workflows to generate and evaluate hypotheses guiding design decisions and influencing project direction.
• Challenge conventional thinking by critically assessing and interpreting computational outputs ensuring robust scientific conclusions.
• Directly contribute to the discovery of innovative medicines by integrating computational chemistry techniques into multidisciplinary drug discovery teams.
• Generate and evaluate hypotheses to assist design decisions and influence project direction by deploying and developing computational methods and workflows
• Work west coast hours and attend regular meetings with our strategic partner in Los Angeles

About You :

Preferred qualifications :

The US base salary range for this full-time position is expected to be $158k - $221k per year. Our salary ranges are determined by role and level. Within the range individual pay is determined by factors including job-related skills experience and relevant education or training. This role may be eligible for annual discretionary bonuses and equity.

SandboxAQ welcomes all.

We are committed to creating an inclusive culture where we have zero tolerance for discrimination. We invest in our employees personal and professional growth. Once you work with us you cant go back to normalcy because great breakthroughs come from great teams and we are the best in AI and quantum technology.

We offer competitive salaries stock options depending on employment type generous learning opportunities medical / dental / vision family planning / fertility PTO (summer and winter breaks) financial wellness resources 401(k) plans and more.

Equal Employment Opportunity : All qualified applicants will receive consideration regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Accommodations : We provide reasonable accommodations for individuals with disabilities in job application procedures for open roles. If you need such an accommodation please let a member of our Recruiting team know.

Required Experience :

Senior IC

Key Skills

Business Consulting,Gas Chromatography,Laboratory Experience,Analytical Chemistry,FDA Regulations,Wet chemistry,Chromatography,High-Performance Liquid Chromatography,Spectroscopy,GLP,cGMP,Organic Chemistry

Employment Type : Full-Time

Experience : years

Vacancy : 1

Yearly Salary Salary : 158 - 221