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Sr / Prin Scientist, Antibody Engineering and Characterization

Sr / Prin Scientist, Antibody Engineering and Characterization

EVOLVEIMMUNE THERAPEUTICS INCBranford, CT, US
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Job Description

Job Description

Senior / Principal Scientist – Antibody Engineering & Characterization

Location : Onsite | Branford, CT | Full-Time

Join a company where your science will directly shape the future of cancer immunotherapy.

Who We Are

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, is anticipated to enter clinical trials in mid-2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of over 45 FTEs in R&D, business development and operations with immediate plans for additional growth. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston / New York City corridor.

We're hiring a Senior or Principal Scientist to join our Biotherapeutics team collaborative group focused on designing and advancing first-in-class immune-engaging biologics. If you’re a protein engineer who thrives in the lab and wants your work to move swiftly toward patients, this role offers real opportunity, purpose, and scientific challenge.

What You’ll Work On

  • Design and optimize novel antibody and bispecific formats that power our next-generation immunotherapies
  • Lead antibody engineering from idea to construct to bench — including expression, purification, and characterization
  • Improve key attributes like affinity, stability, specificity, and PK using modern tools and data
  • Drive developability assessments with platforms like SPR, BLI, DSC, DLS, ciEF, and LC-MS
  • Collaborate across functional teams to support candidate selection and preclinical development
  • Develop and refine functional assays for biologic characterization
  • Present findings in a clear, compelling way to multidisciplinary teams
  • Mentor junior scientists (if interested) and help shape our growing discovery organization

What You Bring

  • PhD in Biochemistry or a related field and 5+ years of industry experience (or)

    • MS with 10+ years in antibody engineering roles

  • Strong foundation in antibody structure–function relationships and biologics drug development
  • Expertise in protein design, expression, purification, and biophysical characterization
  • Deep experience with bispecific or multispecific formats and familiarity with T cell engagers
  • Working knowledge of structure–activity relationships and / or molecular modeling is a plus
  • Experience with mammalian expression systems (e.g., CHO / HEK), cell-based assays, or phage / yeast display is valuable
  • Strong communication, data interpretation, and cross-functional collaboration skills

    • What You’ll Gain

  • A hands-on, high-impact role shaping the design of next-generation immunotherapies
  • Opportunity to see your work move rapidly from concept to clinic
  • A visible position within the Biotherapeutics team, contributing directly to platform and pipeline innovation
  • A chance to collaborate across disciplines and influence key program decisions
  • Professional growth through exposure to diverse scientific challenges and cross-functional projects
  • Optional mentorship opportunities and the ability to help shape a growing discovery organization
  • A mission-driven, fast-paced biotech environment that values bold thinking and scientific excellence
  • A supportive, open culture built on collaboration, trust, and shared purpose

    • Why You’ll Love Working Here

  • Direct impact : Your ideas and experiments will influence platform design and help shape clinical programs
  • Cutting-edge science : Work on a truly novel immunotherapy approach in a scientifically rigorous, fast-moving environment
  • Personal growth : Take on visible, high-impact projects in a startup culture where contributions are recognized and development is supported
  • Collaborative culture : Join a tight-knit, mission-driven team that values open communication, learning, and teamwork
  • Top-tier facilities : Enjoy working in our brand-new, purpose-built lab space just outside New Haven, CT
  • Mission with meaning : Be part of a company working to give more patients real hope in the fight against cancer

    • Additional Info

  • This is a full-time, onsite position based in Branford, CT
  • EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered
  • We offer competitive salary, benefits, equity, and paid time off
  • We are an equal opportunity employer and value diverse perspectives in all aspects of our work

    • Search Keywords

    Antibody Engineering | Bispecific Antibodies | Protein Engineering | Biotherapeutics | Biologics Development | T Cell Engager | Branford Biotech Jobs | Scientist Antibody Discovery | Immunotherapy Careers | Cancer Biotech | Molecular Biology | Biotech Scientist CT | New Haven Biotech | Oncology Drug Discovery | EvolveImmune Careers

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    Scientist Characterization • Branford, CT, US