Vice President, Commercial Operations

Position Summary

Rezolute is a late-stage rare disease company focused on significantly improving outcomes for individuals with hypoglycemia caused by hyperinsulinism (HI). Our antibody therapy, RZ358 (ersodetug), is designed to treat all forms of HI and has shown substantial benefit in clinical trials and real-world use for the treatment of congenital hyperinsulinism (cHI) and tumor hyperinsulinism (tHI)

We are seeking a dynamic and experienced Vice President of Commercial Operations to establish and lead all operational aspects of our commercial strategy in support of the launch of our first rare disease therapy. This includes managing commercial operations functions ensuring the infrastructure, processes, and strategies necessary for successful product launch. This individual will be a strategic and hands‑on leader responsible for building and managing critical commercial infrastructure, including sales operations, analytics, forecasting, market access operations, and commercial systems. This role oversees sales operations, forecasting and analytics, incentive compensation, market research, data management, CRM systems, field effectiveness, and commercial training.

The ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast‑paced environment. The ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast‑paced environment.

Key Responsibilities

• Serve as a key member of the Commercial Leadership Team, developing and executing commercial strategy and operations plans.
• Develop and execute the commercial operations infrastructure to support a successful rare disease product launch.
• Lead commercial planning processes, including sales forecasting, demand planning, incentive compensation design, and territory alignment.
• Build and oversee a high‑functioning sales operations team and associated systems (CRM, data warehousing, reporting dashboards).
• Establish data governance processes and manage third‑party vendors providing data (claims, specialty pharmacy, distribution).
• Partner cross‑functionally with Market Access, Marketing, Medical Affairs, Finance, and IT to ensure alignment of commercial operations with overall corporate goals.
• Design and manage KPIs and reporting frameworks to track performance and inform commercial decision‑making.
• Lead field force enablement efforts, including CRM configuration, targeting, call planning, and field reporting.
• Support the development of compliant policies and processes for commercial activities in collaboration with Legal and Compliance teams.
• Manage operational budgets, contracts, and vendor relationships for commercial functions.

Qualifications

Preferred Attributes

Benefits

Rezolute (RZLT) currently anticipates the base salary for the Vice President of Commercial Operations role could range from $ 330,000 to $360,000 and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate.

Qualifying employees are eligible to participate in benefit programs such as :

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.

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