Director, Translational Medicine and Hematopathology Lead

WHY JOIN US

At AstraZeneca we are dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. With an ambitious goal of delivering 20 new medicines by 2030 there is no better place to make a difference in medicine for patients and in society.

Join us on this exciting journey to pioneer the future of healthcare. Our inclusive culture champions diversity and collaboration and we are always committed to lifelong learning growth and development. As part of our team youll contribute to groundbreaking advancements that will shape a healthier future for people everywhere. Be a catalyst for change at AstraZeneca where your work will have a real impact on improving peoples lives.

Recognizing the importance of individualized flexibility our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week . Our head office is purposely designed with collaboration in mind providing space where teams can come together to strategize brainstorm and connect on key projects.

About the Opportunity :

In this hybrid Director-level role you will lead both program-level translational strategy and hematopathology support across Translational Medicine Hematology. You will own biomarker strategy end to end spanning assay design and validation clinical deployment and decision-enabling data generation from early development through late-stage trials. Partnering with a small team of pathologists and assay scientists as well as external labs and CROs you will ensure delivery of fit-for-purpose HemePath assays (IHC / IF / Flow) and high-quality data that drives patient selection pharmacodynamic insights mechanism-of-action understanding and resistance monitoring.

What Youll Do :

Drive Translational Strategy : Lead end-to-end translational planning for leukemia lymphoma and myeloma programs from preclinical through Phase 3. Embed biomarkers into study protocols and analysis plans define decision points and integrate cytokine flow and other readouts to inform efficacy safety and pharmacodynamics.

Lead Hematopathology Capabilities : Own the heme pathology assay roadmap across IHC IF and flow cytometry. Oversee assay validation quality control and performance monitoring across internal labs and CRO partners. Set interpretation standards and ensure audit-ready pathology and immunophenotyping outputs.

Enable Patient Selection : Design and validate assays for patient selection and enrichment such as antigen-expression or MRD-based strategies. Partner closely with Precision Medicine and Biosamples teams on documentation traceability and potential CDx development.

Shape Portfolio & Cross-Functional Strategy : Collaborate with Oncology Research Clinical Development Clinical Operations and Product Development to align translational and pathology strategies with program goals. Lead internal / external collaborations steer vendors and represent the organization at scientific forums.

Essential Qualifications :

MD (Pathology) with Hematopathology board certification (or international equivalent); or MD / PhD with substantial hematopathology leadership in clinical trials. Exceptional PhD candidates with deep heme pathology and assay leadership experience may be considered.

5 years of pharma / biotech oncology drug development with in-depth translational hematology / oncology expertise.

Proven record of designing validating and operationalizing clinical trial assays including patient selection / enrichment.

Experience with T-cell engagers antibody-drug conjugates and / or cell therapies; understanding of resistance mechanisms.

Strong communication and influence skills; ability to guide decisions at study and program governance forums.

People leadership experience and vendor / CRO oversight; track record of delivering across multi program portfolios.

Demonstrated leadership of HemePath assays :

IHC / IF for hematologic malignancies and TME features

Flow cytometry for blood and bone marrow including rare event detection and MRD-adjacent panels

Desirable Skills and Experience :

Expertise across myeloma leukemia and lymphoma including disease-specific immunophenotyping.

Digital Pathology and AI / ML Integration experience : automated image analysis and / or knowledge of AI / ML tools for pathology interpretation and biomarker scoring; implementation of digital workflows.

Hands-on MRD methodology experience (flow and / or NGS / ctDNA) and clinical deployment.

Familiarity with CDx pathways and regulatory expectations for analytical validation.

Experience integrating multi-omic biomarkers (pathology flow ctDNA cytokines) into clinical decision-making.

The annual base pay for this position ranges from $ 241613.60 - $ 302017.00 pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and experience.

In addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base pay(as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department / team performance and market factors.

SO WHATS NEXT

To be considered for this exciting opportunity please complete the full application on our website at your earliest convenience it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit please share this posting with them.

Are you interested in working at AZ apply today!

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment assessment and selection process and may be requested by emailing .

#LI-Hybrid

Date Posted

03-Dec-2025

Closing Date

02-Dec-2025

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.

Required Experience :

Director

Key Skills

Administrative Skills,Facilities Management,Biotechnology,Creative Production,Design And Estimation,Architecture

Employment Type : Full-Time

Experience : years

Vacancy : 1