Senior Director, Global Safety Physician

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) a serious liver disease that can progress to cirrhosis liver failure need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose : leading the fight against MASH.

Madrigals medication Rezdiffra (resmetirom) is a once-daily oral liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic inclusive and high-performing culture that values scientific excellence operational rigor and collaboration. To support our continued growth we are strengthening our workforce strategy to ensure we have the right talent at the right time in the right way.

Position Responsibilities :

The Director / Sr Dir Global Safety Physician plays a key role in ensuring patient safety in clinical studies and those receiving marketed products. This role is responsible for continuous assessment of safety data signal detection and benefit-risk evaluation for assigned compounds in development and in the postmarketing setting. The role requires strong collaboration within Global Clinical Safety and Pharmacovigilance and across Clinical Development Regulatory Affairs Biostats and Clinical Operations with leadership and key contributions to regulatory filings and global safety governance activities.

The Director / Sr Dir will serve as a medical expert for safety matters supporting both investigational and marketed products. Additionally the role will lead clinical safety strategy author and review safety-related documents and responses to health authority queries and support regulatory interactions.

Key Responsibilities

Medical Oversight & Signal Management

• Provide medical oversight for clinical safety signals including review and interpretation of safety data from clinical trials spontaneous reports and literature.
• Lead or participate in safety signal detection evaluation validation and documentation in collaboration with safety scientists and other stakeholders.
• Serve as a key member or chair of Safety Management Teams (SMTs) contributing to benefitrisk assessments and mitigation strategies.

Regulatory & Scientific Contributions

DSURs PBRERs RMPs IBs and safety sections of clinical study reports

Cross-functional Collaboration

Experience and Professional Qualifications :

The applicant should be a dynamic leader who thrives within a fast-paced growing and collaborative publicly owned biopharmaceutical company :

The ideal candidate displays the following professional competencies :

Educational & Experience :

Madrigals Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

All employees receive equity which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidates qualifications skills education experience business needs and market demands. The base salary range for this position is $318000 - $388000 per year.

All full-time employees receive equity which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits including flexible paid time off medical dental vision and life / disability insurance and 401(k) offerings (i.e. traditional Roth and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance legal services and other addition we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal state and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance please contact

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications merit and business need. Applicants will receive consideration for employment without regard to race ethnicity color religion sex gender identity sexual orientation national origin age disability protected veteran or disabled status or other characteristic protected by applicable federal state or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals Hiring Managers seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigals name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g. fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.

Please also note that any correspondence with regard to employment would come from an authorized email address or from an email address from one of our trusted search firm partners. We are aware that incorrect / fraudulent email addresses with Madrigal misspelled have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal we recommend that you : do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to .

Required Experience :

Exec

Key Skills

EMR Systems,Post Residency Experience,Occupational Health Experience,Pain Management,SOAP,Primary Care Experience,Medical Management,Suturing,Workers' Compensation Law,Pharmacy Residency,Botox Experience,Epic

Employment Type : Full-Time

Experience : years

Vacancy : 1

Yearly Salary Salary : 318000 - 388000