Research Specialist C / D

Research Specialist C / D

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title

Research Specialist C / D

Job Profile Title

Research Specialist C

Job Description Summary

The Research Specialist C / D position in The Center for Cellular Immunotherapies will support research efforts in CAR T-cell therapy development by performing complex in vitro and in vivo experiments.

Job Description

Job Responsibilities

In vitro experiments

• Prepare cell culture materials, media, and reagents.
• Follow established protocols and maintain accurate experimental records.
• Isolate, transduce, transfect, electroporate, expand, formulate, and cryopreserve human T lymphocytes. Perform in vitro experiments to assess T cell phenotype and function (flow cytometry and cocultuure assays).
• Perform molecular assays, optimize experimental conditions.
• Follow standardized protocols and optimize methods to establish in vivo tumor models (IP, IV, orthotopic, subcutaneous) and monitor responses to various cell therapies.
• Perform injections, tumor measurements, imaging, bleeding, necropsy, and tissue harvesting.

Data Acquisition, Analysis, Summarization, Reporting / Presentation

General support to laboratory

In addition to the duties listed, the Research Specialist D will design panels and perform multiparametric flow cytometry for phenotypic characterization of engineered T cells and co-cultures; analyzes datasets using appropriate software. Design, plan and carry out molecular assays. Independently develop protocols, ensure data collected is verified, complete and consistent and properly recorded in digital folders and lab notebook. Provides data summaries, tables, graphs and figures for reports and presentations. Train students and new members on general laboratory procedures, providing advice and mentorship on technical procedures

Qualifications

Research Specialist C

Qualifications preferred :

Experience with imaging modalities for tumor monitoring.

Research Specialist D

Master's degree (Biology, Immunology, or a related scientific discipline) and 3 to 5 years of experience, or an equivalent combination of education and experience.

Extensive in vivo experience with mouse models, including NSG / syngeneic tumor modeling, intravenous (IV), intraperitoneal (IP), and orthotopic injections, tumor measurements, blood sampling, and tissue harvesting.

Strong analytical and decision-making skills to implement assigned projects and troubleshoot technical issues.

Ability to work independently to manage daily research projects, data collection, and laboratory organization.

Excellent organizational and record-keeping skills; ability to manage multiple projects simultaneously.

Strong communication skills and ability to work collaboratively in a team environment.

Preferred :

Familiarity with CAR T-cell manufacturing processes and human primary lymphocyte cultures.

Experience with imaging modalities for tumor monitoring.

Ability to analyze and present data using statistical and graphing software.

Position is contingent upon continued funding.

Job Location - City, State

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$57,500.00 - $78,000.00 Annual Rate

Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job's level. Internal organization and peer data at Penn are also considered.

Equal Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

Special Requirements

Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

Health, Life, and Flexible Spending Accounts : Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.

To learn more, please visit : https : / / www.hr.upenn.edu / PennHR / benefits-pay

Equal Employment Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.

To apply, visit https : / / wd1.myworkdaysite.com / en-US / recruiting / upenn / careers-at-penn / job / Smilow-Center-for-Translational / Research-Specialist-C-D_JR00114694-1

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