Director, Clinical Pharmacology

Overview

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Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

Responsibilities

• Provide strategic insight and technical leadership within the Clinical Pharmacology function.
• Author technical reports and regulatory documents for major milestones of clinical development, specifically IND, EOP1 & EOP2 Briefing Documents. Participate in regulatory interactions and responses to regulatory questions.
• Apply state-of-the-art quantitative modeling, including translational PK / PD, population PK, and exposure–response analyses, to guide recommended phase 2 dose / schedule (RP2Ds) selection for pivotal studies.
• Collaborate with the Discovery organization to support assets in IND-enabling stages, including collaboration with DMPK and Toxicology groups in assessment of human start dose and need for human DDI studies.
• Work with the Clinical Development team in designing FIH studies.
• Design and report Clinical Pharmacology studies such as hADME, Food-Effect and DDI studies.
• Engage and work with CROs on clinical pharmacology activities.
• Represent the Clinical Pharmacology function in project teams and build strong working relationships with cross-functional teams to impact critical decisions.

Qualifications

Preferred Skills

Compensation and Benefits

The base pay salary range for this full-time position for onsite employees in Redwood City, CA is $204,000 — $255,000 USD. The range is base pay and may be adjusted for the local market. Individual base pay is determined by role, level, location, skills, experience, and education or training. This range is one part of the overall total rewards program, which includes competitive cash compensation, equity awards, benefits, and learning opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity / expression, national origin / ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data seriously and respects your privacy. We collect, process and use personal data in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$204,000 — $255,000 USD

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