Senior Medicinal Chemist

Medicinal Chemistry – Senior Principal Scientist / Director / Senior Director

Think Bioscience : We develop small-molecule drugs for historically challenging targets by using our synthetic biology platform to uncover novel mechanisms of biomolecular engagement (e.g., new functional pockets). Our team leverages expertise in synthetic biology, protein biophysics, applied enzymology, computational chemistry, and medicinal chemistry to advance small molecules with biochemical activities previously deemed difficult, if not impossible, to achieve. We are passionate about improving the lives of patients with innovative science. If you share our passion, let’s work together.

About the Position : We are seeking an experienced medicinal chemist as a core member of our chemistry team. This role will work closely with computational chemists, biologists, and external partners to drive SAR exploration and solve challenging problems. The ideal candidate has experience leading medicinal chemistry projects, mentoring junior staff, thrives in a fast-paced environment, and has a strong track record of delivering innovative solutions in drug discovery. This is an on-site position in Boulder, CO.

Responsibilities :

• Lead medicinal chemistry projects to discover high quality development candidates.
• Design and execute synthetic routes to novel small molecules at various production scales, and lead internal and external chemistry teams to deliver material to study sites.
• Drive SAR analysis and compound optimization to improve potency, selectivity, ADME / PK, and safety profiles across multiple programs.
• Collaborate closely with computational chemists, structural biologists, and pharmacologists to integrate data into design strategies.
• Prepare presentations and present data to our internal team and external partners
• Supervise and mentor junior staff.
• Contribute to target selection, platform development, and portfolio strategy.
• Maintain awareness of the latest advances in medicinal chemistry and biophysical methods, including computational tools and high-throughput biochemical methods, and integrate cutting-edge techniques and technologies into Think Bioscience's discovery processes.

Qualifications :

What We Offer :

Think Bioscience is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization or any other non-merit factors.